The son of Philip the Handsome and Joanna the Mad, Charles, took over the reign of Spain from his grandfather Ferdinand and became the new king of Aragon and Castile. He also reigned Navarra, Naples, Sicily and Sardinia as well as territories in America and the Pacific Rim. After Maximilian's death, he also inherited the Habsburg territories. Eventually, Charles reigned an empire "where the sun never set". In 1526, he married Isabella of Portugal and led a very happy marriage.
Charles V was one of the mightiest sovereigns in history. Within his European territory he mainly had to face the challenges of religious conflicts between Catholics and Protestants. Furthermore, he led many wars against France and the Ottoman Empire. Eventually, he resigned and his brother Ferdinand I succeeded him as the emperor. Charles V died 1558 in Spain.